List of Publications

PUBLICATIONS

Optimer Pharmaceuticals, Inc.

“Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities.” Liang, C.-H ; Romero, A.; Rabuka, D.; Sgarbi, P. W. M.; Marby, K. A.; Duffield, J.; Yao, S.; Cheng, M. L; Ichikawa, Y.; Sears, P.; Hu, C.; Hwang, S.-B.; Shue, Y.-K.; Sucheck, S. J. Bioorg. Med. Chem. Lett. 2005, 15, 2123-8 . PubMed - Abstract

“An efficient entry to new sugar modified ketolide antibiotics.” Romero, A.; Liang, C.-H.; Chiu, Y.-H.; Yao, S.; Duffield, J.; Sucheck, S. J.; Marby, K.; Rabuka, D.; Leung, P. Y.; Shue, Y.-K.; Ichikawa, Y.; Hwang, C. -K. Tet. Lett. 2005, 46, 1483-7.

“Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents.” Yao, S.; Sgarbi, P. W. M.; Marby, K. A.; Rabuka, D.; O’Hare, S. M.; Cheng, M. L.; Bairi, M.; Hu, C.; Hwang, S.-B.; Hwang, C.-K.; Ichikawa, Y.; Sears, P.; Sucheck, S. J.Bioorg. Med. Chem. Lett. 2004, 14, 3733-8. PubMed - Abstract

“Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides.” Lee L.V., Bower K.E., Liang F.S., Shi J., Wu D., Sucheck S. J., Vogt P.K., Wong C.-H. J. Am. Chem. Soc.2004; 126, 4774-5. PubMed - Abstract

“Dimeric Aminoglycosides as Antibiotics.” Agnelli, F.; Sucheck, S. J.; Marby, K. A; Rabuka, D.; S.-L., Yao; Sears, P. S.; Liang, F.-S.; Wong, C.-H. Angew. Chem. Int. Ed. 2004,1562-6. PubMed - Abstract

“Combinatorial Synthesis of Aminoglycoside Libraries.” Sucheck, S. J. and Shue, Y.-K. Curr. Opin. Drug Discovery and Development 2001, 4, 462-70. PubMed - Abstract

Postdoctoral

“RNA as a Target for Small Molecules.” Sucheck, S. J.; Wong, C.-H. Curr. Opin. Chem. Biol. 2000, 4, 678-86. PubMed - Abstract

“Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes.” Sucheck, S. J.; Wong, A. L.; Koeller, K. M.; Boehr, D. D.; Draker, K.-A.; Sears, P.; Wright, G. D.; Wong, C.-H.. J. Am. Chem. Soc. 2000, 122, 5230-1.

“Design of Small Molecules that Recognize RNA: Development of Aminoglycosides as Potential Antitumor Agents that Target Oncogenic RNA Sequences.” Sucheck, S. J.; Greenberg, W. A.; Tolbert, T., Wong, C.-H. Angew. Chem., Int. Ed. 2000, 39, 1080-4. PubMed - Abstract

Graduate

“Solid Phase Synthesis and Biochemical Evaluation of Conformationally Constrained Analogues of Deglycobleomycin A 5” Cagir, A.; Tao, Z.-F.; Sucheck, S. J.; Hecht, S. M. Bioorganic Med. Chem. Lett. 2003, 11, 5179-87. PubMed - Abstract

“Study of Naturally Occurring Nucleic Acid Interactive Agents.” Sucheck, S. J. 1998, 205 pp.

“Inhibitors of DNA Polymerase b from Schoepfia Californica.” Chen, J.; Zhang, Y.-H., Wang, L.-K.; Sucheck, S. J.; Snow, A. M.; Hecht, S. M. Chem. Commun. 1998, 2769-70.

“Total Synthesis of Bleomycin Group Antibiotics. The Total Synthesis of Bleomycin Demethyl A 2, Bleomycin A 2 and Decarbamoyl Bleomycin Demethyl A 2.” Katono, K.; An, H.; Aoyagi, Y. Overhand, M.; Sucheck, S. J.; Stevens, W. C. Jr.; Hess, C. D.; Zhou, X.; Hecht, S. M. J. Am. Chem. Soc. 1998, 120, 11285-96.

“Characterization of Zn(II) · Deglycobleomycin A 2 and Interaction with d(CGCATGCG) 2. Direct Evidence for Minor Groove Binding of the Bithiazole Moiety.” Sucheck, S. J.; Ellena, J. F.; Hecht, S. M. J. Am. Chem. Soc.1998, 120, 7450-60.

Undergraduate

“4-Methyl-3,5-dioxopiperazine Acetic Acid and 4-Methyl-3,5-dioxopiperazine-N-methylacetic amide.” Skrzypczak-Jankun, E., Sucheck, S., Smith, D.A. Cambridge Crystallographic Data Centre, deposition no. CCDC 118966/CCDC 118967, 1999.

“Nitrilotriacetamide: Synthesis in Concentrated Sulfuric Acid and Stability in Water” Smith, D. A., Sucheck, S.; Cramer, S.; Baker, D. Synth. Commun. 1995, 25, 4123-32.

“Facile Synthesis of Substituted Nitrilotriacetamides.” Cramer, S.; Sucheck, S. J.; Skrzypczak-Jankun, E.; Smith, D. A. Tetrahedron Lett. 1992, 33, 7765-8.

“Characterization of [Pb(NO 3)(ntam) 2]NO 3 the First Metal Complex of the Neutral Tetradentate Ligand Nitrilotriacetamide (ntam).” Sucheck, S. J.; Pinkerton, A. A.; Smith, D. A. J. Chem. Soc., Chem. Commun.1992, 367-8.

PATENTS and PATENT APPLICATIONS

“Novel Antibacterial Agents.” Liang, C.-H.; Duffield, J.; Romero, A.; Chiu, Y.-H.; Rabuka, D.; Yao, S., Sucheck, S. J.; Marby, K. A.; Shue, Y.-K.; Ichikawa, Y.; Hwang, C.-K. U.S. Publication No. US2006/0100164 A1; 2006.

“ New Aminoglycoside Antibiotics as Novel Anti-Infective Agents.” Liang, C.-H.; Marby, K. A.; Rabuka, D.; Romero, A.; Sgarbi, P. W. M.; Sucheck, S. J.; Shue Y.-K; Yao S. U.S. Publication No. US2004058880 A1

“Bifunctional Antibiotics.” Sucheck, S. J. and Wong, C.-H. Issued July 26 th, 2005, Pat No. 6,921,818 .

NEWS FEATURES COVERING WORK

“Carbohydrate Vaccines.” Chemical & Engineering News, 2004, 82(32), 31-35.

“Chemistry Highlights 2000.” Chemical & Engineering News, 2000 , 78(51), 24-31.

“Targeting RNA.” Chemical & Engineering News, 2000 , 78(40), 54-57.

“Against Bifuctional Antibiotics, Resistance Is Futile.” Chemical & Engineering News, 2000 , 78(22), 12.

“Antibiotic, Modified Neamine, Scripps Research Institute and Scripps Clinic Research Foundation Develops Antibiotic.” R & D Focus Drug News, July 3 rd, 2000.

“New Approach to Antibiotic Resistance.” EurekAlert, June 8 th, 2000.

“Lifelines: Trumping Bacterial Resistance.” Nature Science Update, June 12 th, 2000.

Take me back to Steve Sucheck's Page or to the UT-Chemistry Home Page