Prof. Jon R. Kirchhoff
Chemistry Department
2265 WO
University of Toledo
Kirchhoff Faculty Page
Current and Former Group Members
| JON
R. KIRCHHOFF Professor |
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| Professional Background:
B.A., 1979, State University of New York at Cortland Ph.D., 1985, Purdue University Postdoctoral Fellow, 1985-1989, University of Cincinnati. |
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| Email: Office: |
jkirchh@uoft02.utoledo.edu WO 2265 |
Phone: Fax: |
(419)
530-1515 (419) 530-4033 |
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Research
Synopsis:
Research in my group revolves around the
general theme of developing analytical methodology that enhances
selectivity and sensitivity for chemical measurements. This could
involve detection of analytes in complex mixtures or at trace
levels. Numerous approaches to enhanced selectivity are employed
such as the high efficiency of capillary electrophoresis (CE)
separations, the development of electrochemical-based sensor
devices with analyte specific recognition elements, or the
combination of CE with microelectrode sensors as the detector.
All of these approaches also lower the level at which detection
and quantitation can be confidently made.
Research projects are interdisciplinary in nature, spanning many
subdisciplines of chemistry and impacting all areas of chemistry.
Graduate and undergraduate students have utilized CE to develop
separations for isomeric o-quinones and chiral drug compounds,
fabricated biocatalytic electrodes for the measurement of the
neurotransmitter acetylcholine and its metabolic precursor choline,
as well as thiols at the femtomole (10-15) level,
developed assays for investigating the inhibition of choline
uptake in synaptosome preparations by a new class of organic-based
redox inhibitors synthesized in Dr. Richard Hudson’s laboratory,
discovered novel chemical vapor deposition techniques to fabricate
disk and ring-disk microelectrodes, specific sensor devices, and
new optically transparent electrodes for spectroelectrochemical
measurements, and synthesized and characterized novel luminescent
rhenium(II) transition metal complexes. The details of many of
these projects can be found in the publications on this web site.
Scanning Electron Micrograph of a 10µm Carbon Fiber coated with
Silica by Chemical Vapor Deposition
Capillary Electrophoretic Separation and Detection of the
Neurotransmitter Acetylcholine, Choline, and the Internal Standard
Butyrylcholine with an Enzyme Modified Microelectrode
Determination of Cysteine in Human Urine by Capillary
Electrophoresis at a Biocatalytic Thiol Selective Microelectrode
Detector. Cysteine labeled as c. A is urine only,
while B is urine plus cysteine spike
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